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  string(9) "林东昕"
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  string(34308) "中国工程院院士、研究员(教授)、博士生导师。现任中国医学科学院北京协和医学院肿瘤医院病因及癌变研究室主任，癌发生及预防分子机理北京市重点实验室主任；北京协和医学院学术委员会委员，北京大学医学部学术委员会委员，分子肿瘤学国家重点实验室学术委员。 1986  年北京医科大学研究生毕业，医学硕士学位。 1988 年 8 月至 1990 年 6 月在法国国家科学研究中心肿瘤研究所和世界卫生组织国际癌症研究中心 (  IARC  ) ， 1990 年 7 月至 1994 年 8 月在美国国家毒理学研究中心从事肿瘤基础研究。 1995 到肿瘤医院肿瘤研究所工作。国家杰出青年科学基金获得者 ( 1998年 )；卫生部有突出贡献中青年专家(2003 - 2004年度 ) ；国务院颁发政府特殊津贴专家 (2001年) 。2013年当选为中国工程院院士。

学术兼职：中国抗癌协会理事、肿瘤病因专业委员会主任委员，中国吸烟与健康协会理事；国际专业期刊 Int J Cancer、PharmacogenetGenomics、Biomed Environ Sci，国内专业期刊《中华肿瘤杂志》和《癌症》等编委。研究领域为常见肿瘤发生发展及其遗传易感性的分子机制；肿瘤分子流行病学； 个体化医学。曾承担和正在承担国家 " 973 " 重大基础研究规划、 国家" 863 "高技术项目、 国家自然科学基金重大项目、 国家自然科学基金重点项目、国家杰出青年科学基金项目、国家医学科技攻关项目等重要的科研项目。

主要学术贡献：揭示并阐明我国食管癌、 胰腺癌、 肺癌等肿瘤的易感基因及基因 - 环境交互作用、 遗传变异对肿瘤放化疗疗效及预后的影响。 至 2014 年已发表科学论文 210 余篇， 其中13篇发表在遗传学领域顶级期刊Nature Genetics。论文累计SCI影响因子1100 多分，被引用 9500 多次。参与主编或编写《肿瘤遗传学》、《肿瘤学》、《临床肿瘤学》等专著。研究成果获2006年国家自然科学奖二等奖、2008年国家科技进步奖二等奖和2011年教育部自然科学奖一等奖等。发表在Nature Genetics的文章( Sun et al, Nat Genet 2007; 39: 605 - 613 )被评为 2007 年度中国基础研究十大新闻。已培养肿瘤学毕业博士研究生 20 余名，其中 4 名博士研究生论文被评为 2006 、 2008 、 2009 年和 2013 年全国优秀博士学位论文。



发表论文目录（* 通讯作者或第一作者）

1.Chu M, Zhang R, Zhao Y, Wu C, Guo H, Zhou B, Lv J, Shi Y, Dai J, Jin G, Ma H, Dong J, Wei Y, Wang C, Gong J, Sun C, Zhu M, Qiu Y, Wu T, Hu Z, Lin D, Shen H, Chen F*.A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung cancer susceptibility in Han Chinese. Carcinogenesis 2013 Dec 9 [Epub ahead of print]



2.Wu C, Kraft P, Stolzenberg-Solomon R, Steplowski E, Brotzman M, Xu M, Mudgal P, Amundadottir L, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, Kooperberg C, Petersen GM, Zheng W, Albanes D, Boutron-Ruault M-C, Buring JE, Canzian F, Cao G, Duell EJ, Elena JL, Gaziano JM…Fuchs CS, Lin D*, Wolpin BM*. Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut 2014;63:152–160.



3.He M*, Wu C*, Xu J*, Guo H*, Yang H, Zhang X, Sun J, Yu D, Zhou L, Peng T, He Y, Gao Y, Yuan J, Deng Q, Dai X, Tan A, Feng Y, Zhang H, Min X, Yang X, Zhu J, Zhai K, Chang J, Qin X, Tan W, Hu Y, Lang M, Tao S, Li Y, Li Y, Feng J, Li D, Kim ST, Zhang S, Zhang H, Zheng SL, Gui L, Wang Y, Wei S, Wang F, Fang W, Liang Y, Zhai Y, Chen W, Miao X, Zhou G, Hu FB, Lin D, Mo Z, Wu T*. A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigenα fetoproteintheir associations with cancer risk. Gut 2014;63:143–151.



4.Li J, Gui L, Wu C, He Y, Zhou L, Guo H, Yuan J, Yang B, Dai X, Deng Q, Huang S, Guan L, Hu D, Deng S, Wang T, Zhu J, Min X, Lang M, Li D, Yang H, Hu FB, Lin D, Wu T, He M*. Genome-wide association study on serum alkaline phosphatase levels in a Chinese population. BMC Genomics 2013; 14:684.



5.Shi Y, Li L, Hu Z, Li S, Wang S, Liu J, Wu C, He L, Zhou J, Li Z, Hu T, Chen Y, Jia Y, Wang S, Wu L, Cheng X, Yang Z, Yang R, Li X, Huang K, Zhang Q, Zhou H, Tang F, Chen Z, Shen J, Jiang J, Ding H, Xing H, Zhang S, Qu P, Song X, Lin Z, Deng D, Xi L, Lv W, Han X, Tao G, Yan L, Han Z, Li Z, Miao X, Pan S, Shen Y, Wang H, Liu D, Gong E, Li Z, Zhou L, Luan X, Wang C, Song Q, Wu S, Xu H, Shen J, Qiang F, Ma G, Liu L, Chen X, Liu J, Wu J, Shen Y, Wen Y, Chu M, Yu J, Hu X, Fan Y, He H, Jiang Y, Lei Z, Liu C, Chen J, Zhang Y, Yi C, Chen S, Li W, Wang D, Wang Z, Di W, Shen K, Lin D, Shen H, Feng Y, Xie X, Ma D*. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q1217q12. Nat Genet 2013; 45:918–922.



6. Du J, Xu Y, Dai J, Ren C, Zhu C, Dai N, Ma H, Shi Y, Hu Z, Lin D, Shen H, Jin G*. Genetic variants at 5p15 are associated with riskearly-onset of gastric cancer in Chinese populations. Carcinogenesis 2013; 34:2539–2542.



7.Tan DE, Foo JN, Bei JX, Chang J, Peng R, Zheng X, Wei L, Huang Y, Lim WY, Li J, Cui Q, Chew SH, Ebstein RP, Kuperan P, Lim ST, Tao M, Tan SH, Wong A, Wong GC, Tan SY, Ng SB, Zeng Y, Khor CC, Lin D*, Seow AL*, Jia W*, Liu J*. Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nat Genet 2013; 45:804–807.



8.Zhang X, Wei J, Zhou L, Zhou C, Shi J, Yuan Q, Yang M*, Lin D. A functional BRCA1 coding sequence genetic variant contributes to risk of esophageal squamous cell carcinoma. Carcinogenesis 2013; 34:2309–2313.



9. Wu C, Li D, Jia W, Hu Z, Zhou Y, Yu D, Tong T, Wang M, Lin D, Qiao Y, Zjou Y, Chang J, Zhai K, Wang M, Wei L, Tan W, Shen H, Zeng Y, Lin D*. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma patients. Nat Genet 2013; 45:632–638.



10.Deng Q, Guo H, Dai J, Yang L, Wu C, Wang Q, Hu Z, Yang M, Liu L, Yu D, Hu D, Hong X, Qiu F, Yang H, Wang T, Tan W, Chu M, Feng J, Teng K, Gong J, Sun C, Hu X, Zhang K, Lu J, Lin D, Shen H, Wu T*. Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6SH3RF1their interactions with smoking in Chinese populations. Carcinogenesis 2013; 34:2010–2016.



11.Chang J, Huang Y, Wei L, Ma B, Miao X, Li Y, Hu Z, Yu D, Jia W, Liu Y, Tan W, He Z, Ke Y, Wu T, Shen H, Zeng Y, Wu C*, Lin D*. Risk prediction of esophageal squamous-cell carcinoma with common genetic variantslife-style factors in Chinese population. Carcinogenesis 2013; 34:1782–1786.



12.Qiao Y, Zhou Y, Wu C, Zhai K, Han X, Chen J, Tian X, Chang J, Lu Z, Zhang B, Yu D, Yao J, Shi Y*, Tan W*, Lin D. Risk of genome-wide association study-identified genetic variants for NHL in a Chinese population.Carcinogenesis 2013; 34:1516–1519.



13.Wu C, Chang J, Ma B, Miao X, Zhou Y, Liu Y, Li Y, Wu T, Hu Z, Shen H, Jia W, Zeng Y, Lin D*, Kraft P*. The case-only test of gene-environment interaction is not uniformly powerful: An empirical example. Genet Epidemiol 2013; 37:402–407.



14.Zhang R, Zhao Y, Chu M, Wu C, Jin G, Dai J, Wang C, Hu L, Gou J, Qian C, Bai J, Wu T, Hu Z, Lin D, Shen H, Chen F*. Pathway analysis for genome-wide association study of lung cancer in Han Chinese population.PLoS One 2013; 8:e57763.



15.Ma F, Zhang P, Lin D, Yu D, Yuan P, Wang J, Fan Y, Xu B*. There Is No association between microRNA gene polymorphismsrisk of triple negative breast cancer in a Chinese Han population. PLoS One 2013; 8:e60195.



16.Dai X, Wu C, He Y, Gui L, Zhou L, Guo H, Yuan J, Yang B, Li J, Deng Q, Huang S, Guan L, Hu D, Zhu J, Min X, Lang M, Li D, Yang H, Hu FB, Lin D, Wu T, He M*. A genome-wide association study for serum bilirubin levelsgene-environment interaction in a Chinese population. Genet Epidemiol 2013; 37:293–300.



17.Dong J, Jin G, Wu C, Guo H, Zhou B, Lv J, Lu D, Shi Y, Shu Y, Xu L, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Yu D, Ma H, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Cao S, Qin Z, Gong J, Sun C, Wang J, Wu W, Zhou G, Chen H, Guan P, Chen Y, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Liu J, Amos CI, Chen F, Tan W, Jin L, Wu T, Hu Z*, Lin D*, Shen H*. Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in Han Chinese. PLoS Genet 2013; 9:e1003190.



18.Huang L, Wu C, Yu D, Wang C, Che X, Miao X, Zhai K, Chang J, Jiang G, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Tan W, Wu T, Lin D*. Identification of common variants in BRCA2MAP2K4 for susceptibility to sporadic pancreatic cancer. Carcinogenesis 2013; 34:1001–1005.



19.Zhang T, Cai J, Chang J, Yu D, Wu C, Yan T, Zhai K, Bi X, Zhao H, Xu J, Tan W, Qu C, Lin D*. Evidence of associations of APOBEC3B gene deletion with susceptibility to persistent HBV infectionhepatocellular carcinoma. Hum Mol Genet 2013; 22:1262–1269.



20.Liu L, Wu J, Zhong R, Wu C, Zou L, Yang B, Chen W, Zhu B, Duan S, Yu D, Tan W, Nie S, Lin D*, Miao X*.Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer.Mol Carcinog 2013; 52:923–931.



21.Jiang DK*, Sun J*, Cao G*, Liu Y*, Lin D*, Gao YZ, Ren WH, Long XD, Zhang H, Ma XP, Wang Z, Jiang W, Chen TY, Gao Y, Sun LD, Long JR, Huang HX, Wang D, Yu H, Zhang P, Tang LS, Peng B, Cai H, Liu TT, Zhou P, Liu F, Lin X, Tao S, Wan B, Sai-Yin HX, Qin LX, Yin J, Liu L, Wu C, Pei Y, Zhou YF, Zhai Y, Lu PX, Tan A, Zuo XB, Fan J, Chang J, Gu X, Wang NJ, Li Y, Liu YK, Zhai K, Zhang H, Hu Z, Liu J, Yi Q, Xiang Y, Shi R, Ding Q, Zheng W, Shu XO, Mo Z, Shugart YY, Zhang XJ, Zhou G, Shen H, Zheng SL, Xu J*, Yu L*. Genetic variants in STAT4HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet 2012; 45:72–75.



22.Wu C, Kraft P, Zhai K, Chang J, Zhao W, Li Y, Hu Z, He Z, Jia W, Abnet CC, Liang L, Hu N, Miao X, Zhou Y, Liu Z, Zhan Q, Liu Y, Qiao Y, Zhou Y, Jin G, Guo C, Lu C, Yang H, Fu J, Yu D, Freedman ND, Ding T, Tan W, Goldstein AM, Wu T, Shen H, Ke Y, Zeng Y, Chanock SJ, Taylor PR, Lin D*. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility locigene-environment interactions.Nat Genet 2012; 44:1090–1097.



23.Lan Q, Hsiung CA, Matsuo K, …, Wu T*, Wu Y*, Yang P-C*, Zhou B*, Shin M-H*, Fraumeni Jr F*, Lin D*, Chanock SJ*, Rothman N*. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.Nat Genet 2012; 44:1330–1335 (*Jointly directed this study).



24.Jin G, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y, Chen J, Li H, Pan S, Chu M, Yu D, Jiang Y, Dong J, Hu L, Chen Y, Xu L, Shu Y, Pan S, Tan W, Zhou B, Lu D, Wu T, Zhang Z, Chen F, Wang X, Hu Z*, Lin D*, Shen H. Genetic variants at 6p21.17p15.3 are associated with risk of multiple cancers: evidence from three genome-wide association studies on different cancers in Han Chinese populations. Am J Hum Genet 2012; 91:928–934.



25.Hu L, Wu C, Zhao X, Heist RS, Su L, Zhao Y, Han B, Cao S, Chu M, Dai J, Dong J, Shu Y, Xu L, Chen Y, Wang Y, Lu F, Jiang Y, Yu D, Chen H, Tan W, Ma H, Chen J, Jin G, Wu T, Lu D, Christiani DC, Lin D, Hu Z, Shen H*. Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. Clin Cancer Res 2012; 18:5507–5514.



26.Li S, Qian J, Yang Y, Zhao W, Dai J, Bei JX, Foo JN, McLaren PJ, Li Z, Yang J, Shen F, Liu L, Yang J, Li S, Pan S, Wang Y, Li W, Zhai X, Zhou B, Shi L, Chen X, Chu M, Yan Y, Wang J, Cheng S, Shen J, Jia W, Liu J, Yang J, Wen Z, Li A, Zhang Y, Zhang G, Luo X, Qin H, Chen M, Wang H, Jin L, Lin D, Shen H, He L, de Bakker PI, Wang H, Zeng YX, Wu M, Hu Z, Shi Y, Liu J, Zhou W*. GWAS identifies novel susceptibility loci on 6p21.3221q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet 2012; 8(7):e1002791.



27.Dong J#, Hu Z#, Wu C#, Guo H, Zhou B, Lv J, Lu D, Chen K, Shi Y, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Cao S, Qin Z, Yu D, Ma H, Jin G, Gong J, Sun C, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Wang J, Wu W, Zheng H, Zhou G, Chen H, Guan P, Peng Z, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Amos CI, Chen F, Tan W, Jin L, Wu T, Lin D, Shen H*. Association analyses identify multiple new lung cancer susceptibility locitheir interactions with smoking in the Chinese population. Nat Genet 2012; 44:895–899.



28.Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, Wenzlaff AS, Wu C, Yoon D, Chen YT, Cheng YC, Cho YS, David SP, Duan J, Eaton CB, Furberg H, Goate AM, Gu D, Hansen HM, Hartz S, Hu Z, Kim YJ, Kittner SJ, Levinson DF, Mosley TH, Payne TJ, Rao DC, Rice JP, Rice TK, Schwantes-An TH, Shete SS, Shi J, Spitz MR, Sun YV, Tsai FJ, Wang JC, Wrensch MR, Xian H, Gejman PV, He J, Hunt SC,Kardia SL, Li MD, Lin D, Mitchell BD, Park T, Schwartz AG, Shen H, Wiencke JK, Wu JY, Yokota J, Amos CI, Bierut LJ*. Smokinggenetic risk variation across populations of European, Asian,African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol 2012; 36:340–351.



29.Dey S, Maiti AK, Hegde ML, Hegde PM, Boldogh I, Sarkar PS, Abdel-Rahman SZ, Sarker AH, Hang B, Xie J, Tomkinson AE, Zhou M, Shen B, Wang G, Wu C, Yu D, Lin D, Cardenas V, Hazra TK*. Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. DNA Repair (Amst) 2012; 11:570–578.



30.Hosgood HD 3rd, Wang WC, Hong YC, Wang JC, Chen K, Chang IS, Chen CJ, Lu D, Yin Z, Wu C, Zheng W, Qian B, Park JY, Kim YH, Chatterjee N, Chen Y, Chang GC, Hsiao CF, Yeager M, Tsai YH, Wei H, Kim YT, Wu W, Zhao Z, Chow WH, Zhu X, Lo YL, Sung SW, Chen KY, Yuenger J, Kim JH, Huang L, Chen YH, Gao YT, Kim JH, Huang MS, Jung TH, Caporaso N, Zhao X, Huan Z, Yu D, Kim CH, Su WC, Shu XO, Kim IS, Bassig B, Chen YM, Cha SI, Tan W, Chen H, Yang TY, Sung JS, Wang CL, Li X, Park KH, Yu CJ, Ryu JS, Xiang Y, Hutchinson A, Kim JS, Cai Q, Landi MT, Lee KM, Hung JY, Park JY, Tucker M, Lin CC, Ren Y, Perng RP, Chen CY, Jin L, Chen KC, Li YJ, Chiu YF, Tsai FY, Yang PC, Fraumeni JF Jr, Seow A, Lin D, Zhou B, Chanock S, Hsiung CA, Rothman N, Lan Q*. Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia.Hum Genet 2012; 131:1197–1203.



31.Zhai K , Tian X, Wu C, Lu N, Chang J, Huang L, Zhang T, Zhou Y, Qiao Y, Yu D, Tan W, Chen J*, Lin D*. Cytokine BAFF gene variation is associated with survival of patients with T-cell lymphoma. Clin Cancer Res 2012; 18:2250–2256.



32.Wu C, Miao X, Huang L, Che C, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C*, Lin D*. Genome-wide association study identif five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet 2012; 44:62–66.



33.Huang L, Yu D, Wu C, Zhai K, Jiang G, Cao G, Wang C, Liu Y, Sun M, Li Z, Tan W, Lin D*. Copy number variation at 6q13 functions as a long-range regulatoris associated with pancreatic cancer risk. Carcinogenesis 2012; 33:94–100.



34.Jiang Y, Wang W, Wang J, Lu Y, Chen Y, Jin L, Lin D, He F, Wang H*. Functional regulatory variants of MCL1 contribute to enhanced promoter activityreduced risk of lung cancer in nonsmokers: Implications for context-dependent phenotype of an antiapoptoticantiproliferative gene in solid tumor. Cancer 2011; 118:2085–2095.



35.Guo H, Deng Q, Wu C, Hu L, Wei S, Xu P, Kuang D, Liu L, Hu Z, Miao X, Shen H, Lin D, Wu T*. Variations in HSPA1B at 6p21.3 are associated with lung cancer riskprognosis in Chinese populations.Cancer Res 2011; 71:7576–7586.



36.Shi Y*, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Hu L, Jiang Y, Li Z, Chu M, Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D*, Shen H*. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.315p13.1. Nat Genet 2011; 43:1215–1218.



37.Liu L, Wu J, Wu C, Wang Y, Zhong R, Zhang X, Tan W, Nie S, Miao X, Lin D*. A functional polymorphism (–1607 1G→2G) in the matrix metalloproteinase-1 promoter is associated with developmentprogression of lung cancer. Cancer 2011; 117:5172–5181.



38.Liu L, Wu C, Wang Y, Zhong R, Duan S, Wei S, Lin S, Zhang X, Tan W, Yu D, Nie S, Miao X, Lin D*. Combined effect of genetic polymorphisms in P53, P73,MDM2 on non-small cell lung cancer survival. J Thorac Oncol 2011; 6:1793–1800.



39.Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, Yang L, Dai J, Hu L, Tan W, Li Z, Deng Q, Wang J, Wu W, Jin G, Jiang Y, Yu D, Zhou G, Chen H, Guan P, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Ma H, Chen J, Chu M, Lu F, Zhang Z, Chen F, Wang X, Jin L, Lu J, Zhou B, Lu D, Wu T, Lin D, Shen H*. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.1222q12.2 in Han Chinese.Nat Genet 2011; 43:792–796.



40.Xiong F, Wu C, Chang J, Yu D, Xu B, Yuan P, Zhai K, Xu J, Tan W, Lin D*. Genetic variation in MiRNA-1827 binding site of MYCL1susceptibility to small-cell lung cancer. Cancer Res 2011; 71:5175–5181.



41.Wu C, He Z, Hu Z, Jia W, Wang F, Liu Z, Zhan Q, Liu Y, Yu D, Liu Z, Shen Y, Zhai K, Chang J, Qiao Y, Guo C, Jin G, Fu J, Miao X, Tan W, Wu T, Ke Y, Shen H, Zeng Y, Lin D*. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet 2011; 43:679–684.



42.Liu L, Yuan P, Wu C, Zhang X, Wang F, Guo H, Zhong R, Xu Y, Wu J, Yu D, Wu T, Zhang X, Nie S*, Miao X*, Lin D. Assessment of XPD Lys751GlnXRCC1 T-77C polymorphisms in advanced non-small-cell lung cancer patients treated with platinum-based chemotherapy. Lung Cancer 2011; 73:110–115.



43.Yang M, Zhang L, Bi N, Ji W, Tan W, Zhao J, Yu D, Wu C, Wang L, Lin D*. Association of P53ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patient treated with radiotherapy.Int J Radiat Oncol Biol Phys 2011; 79:1402–1407.



44.Knappskog S, Bj?rnslett M, Myklebust LM, Huijts PE, Vreeswijk MP, Edvardsen H, Guo Y, Zhang X, Yang M, Ylisaukko-Oja SK, Alhopuro P, Arola J, Tollenaar RA, van Asperen CJ, Seynaeve C, Staalesen V, Chrisanthar R, L?kkevik E, Salvesen HB, Evans DG, Newman WG, Lin D, Aaltonen LA, B?rresen-Dale AL, Tell GS, Stoltenberg C, Romundstad P, Hveem K, Lillehaug JR, Vatten L, Devilee P, D?rum A, L?nning PE. The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor bindingreduces risk for breastovarian cancer in Caucasians.Cancer Cell 2011; 19:273–282.



45.Liu L, Wu C, Wang Y, Zhong R, Wang F, Zhang X, Duan S, Lou J, Yu D, Tan W, Yuan J, Wu T, Nie S*, Miao X*, Lin D*. Association of candidate genetic variations with gastric cardia adenocarcinoma in Chinese population: a multiple-interaction analysis. Carcinogenesis 2011; 32:336–342.



46.Zhang B, Sun T, Zhang B, Zheng S, Lu N, Xu B, Wang X, Cheng G, Yu D, Lin D*. Polymorphisms of GSTP1 is associated with differences of chemotherapy responsetoxicity in breast cancer. Chinese Med J 2011; 124:199–204.



47.Xu J, Wu, C Wu, Che X, Wang Li, Yu D, Zhang T, Huang L, Li H, Tan W, Wang C*, Lin D*. Circulating microRNAs, miR-21, miR-122miR-223, in patients with hepatocellular carcinomachronic hepatitis.Mol Carcinogen 2011; 50:136–142.



48.Chen X, Li H, Qiao Y, Yu D, Guo H, Tan W*, Lin D. Association of CD28 gene polymorphism with cervical cancer risk in a Chinese population. Int J Immunogenet 2011; 38:51–54.



49.Cao Y, Miao X, Huang M, Deng L, Lin D, Zeng Y, Shao J*. Polymorphisms of death pathway genes FASFASLrisk of nasopharyngeal carcinoma.Mol Carcinogen 2010; 49:944–950.



50.Cao Y, Miao X, Huang M, Xiong F, Deng L, Liang X, Lin D, Zeng Y, Shao J*. Polymorphisms of methylenetetrahydrofolate reductase are associated with a high risk of nasopharyngeal carcinoma in a smoking population from southern China. Mol Carcinogen2010; 49:928–934.



51.Liu L, Yuan P, Liu L, Wu C, Zhang X, Guo H, Zhong R, Xu Y, Wu J, Duan S, Rui R, Wu T, Nie S, Miao X*, Lin D. A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat 2010; 125:479–487.



52.Yuan P, Liu L, Wu C, Zhong R, Yu D, Wu J, Xu Y, Nie S, Miao X, Xu B, Lin D*. No association between 1 XRCC1 polymorphismssurvival in non-small-cell lung cancer patients treated with platinum-based chemotherapy.Cancer Biol Ther 2010; 10:854–859.



53.Wu C, Xu B, Yuan P, Miao X, Liu Y, Guan Y, Yu D, Xu J, Zhang T, Shen H, Wu T, Lin D*. Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patients. Cancer Res 2010; 70:9721–9729.



54.Guo Y, Zhang X, Yang M, Miao X, Shi Y, Yao J, Tan W, Sun T, Zhao D, Yu D, Liu J, Lin D*. Functional evaluation of missense variations in the human MAD1L1MAD2L1 genestheir impact on susceptibility to lung cancer.J Med Genet 2010; 47:616–622.



55.Zhang L, Yang M, Bi N, Ji W, Wu C, Tan W, Zhao L, Yu D, Lin D*, Wang L*. Association of TGF-β1XPD polymorphisms with severe acute radiation-induced esophageal toxicity in locally advanced lung cancer patients treated with radiotherapy. Radiother Oncol 2010; 97:19–25.



56.Hsiung CA, Lan Q*, Hong YC, Chen CJ, Hosgood HD, Chang IS, Chatterjee N, Brennan P, Wu C, Zheng W, Chang GC, Wu T, Park JY, Hsiao CF, Kim YH, Shen H, Seow A, Yeager M, Tsai YH, Kim YT, Chow WH, Guo H, Wang WC, Sung SW, Hu Z, Chen KY, Kim JH, Chen Y, Huang L, Lee KM, Lo YL, Gao YT, Kim JH, Liu L, Huang MS, Jung TH, Jin G, Caporaso N, Yu D, Kim CH, Su WC, Shu XO, Xu P, Kim IS, Chen YM, Ma H, Shen M, Cha SI, Tan W, Chang CH, Sung JS, Zhang M, Yang TY, Park KH, Yuenger J, Wang CL, Ryu JS, Xiang Y, Deng Q, Hutchinson A, Kim JS, Cai Q, Landi MT, Yu CJ, Park JY, Tucker M, Hung JY, Lin CC, Perng RP, Boffetta P, Chen CY, Chen KC, Yang SY, Hu CY, Chang CK, Fraumeni JF Jr, Chanock S, Yang PC, Rothman N, Lin D. The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet 2010; 6(8):e1001051.



57.Zhang H, Zhai Y, Hu Z, Wu C, Qian J, Jia W, Ma F, Huang W, Yu L, Yue W, Wang Z, Li P, Zhang Y, Liang R, Wei Z, Cui Y, Xie W, Cai M, Yu X, Yuan Y, Xia X, Zhang X, Yang H, Qiu W, Yang J, Gong F, Chen M, Shen H, Lin D, Zeng Y, He F*, Zhou G*. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet 2010; 42;755–758.



58.Xiong F, Wu C, Bi X, Yu D, Huang L, Xu J, Zhang T, Zhai K, Chang J, Tan W, Cai J*, Lin D*. Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population.Cancer Epidemiol Biomarkers Prev 2010; 19:1855–1861.



59.Wu C, Xu B, Yuan B, Ott J, Guan Y, Liu Y, Liu Z, Shen Y, Yu D, Lin D*. Genome-wide examination of genetic variants associated with response to platinum-based chemotherapy in patients with small-cell lung cancer.Pharmacogenet Genomics 2010; 20:389–395.



60.Zhang L, Yang M, Bi N, Fang M, Sun T, Ji W, Tan W, Zhao L, Yu D, Lin D*, Wang L*. ATM polymorphisms are associated with risk of radiation-induced pneumonitis. Int J Radiat Oncol Biol Phys 2010; 77:1360–1368.



61.Xiong J, Yu D, Wei N, Fu H, Cai T, Huang Y, Wu Chen, Zheng X, Du Q, Lin D*, Liang Z*. An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha positive human breast cencer cell linesclinical samples. FEBS J 2010; 277:1684–1694.



62.Bi N, Yang M, Zhang L, Chen X, Ji W, Ou G, Lin D*, Wang L*. Cyclooxygenase-2 genetic variants are associated with survival in unrsectable locally advanced non-small-cell lung cancer. Clin Cancer Res 2010; 16:2383–2390.



63.Tai J, Yang M, Ni, Yu D, Fang J, Tan W, Huang Z, Wu C, Chen X, Wang, Zhou W, Chen X, Zhang W, Ma L, Lin D*, Han D*. Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynxhypopharynx in a Chinese population. Cancer Genet Cytogenet 2010; 196:76–82.



64.Zhang W, Chen X, Luo A, Lin D, Tan W*, Liu Z*. Genetic variants of C1orf10risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Sci 2009; 100:1695–1700.



65.Wu C, Wang G, Huang L, Yu D, Tan W, Lin D*. Two genetic variants in prostate stem cell antigengastric cancer susceptibility in a Chinese population.Mol Carcinogen 2009; 48:1131–1138.



66.Zhao D, Zhang X, Guo Y, Tan W, Lin D*. Cyclooxygenase-2 Gly587Arg variant is associated with differential enzymatic activityrisk of esophageal squamous-cell carcinoma. Mol Carcinogen 2009; 48:934–941.



67.Yang M, Guo H, Wu C, He Y, Yu D, Zhou L, Wang F, Xu J, Tan W, Wang G, Shen B, Yuan J, Wu T, Lin D*. Functional FEN1 polymorphisms are associated with DNA damage levelslung cancer risk. Hum Mutat 2009; 30:1320–1328.



68.Ma F, Sun T, Shi Y, Yu D, Tan W, Yang M, Wu C, Chu D, Sun Y, Xu B*, Lin D*. Polymorphisms of EGFR predict clinical outcome in advanced non-small-cell lung cancer patients treated with Gefitinib.Lung Cancer 2009; 66:114–119.



69.Sun T, Hu Z, Shen H, Lin D*. Genetic polymorphisms in cytotoxic T-lymphocyte antigen 4cancer: the dialectical nature of subtle human immune dysregulation. Cancer Res 2009; 69:6011–6014.



70.Wang G, Yu D, Tan W, Zhao D, Wu C, Lin D*. Genetic polymorphism in chemokine CCL22susceptibility to Helicobacter pylori infection-related gastric carcinoma.Cancer 2009; 115:2430–2437.



71.Wu C, Hu Z, Yu D, Huang L, Jin G, Liang J, Guo H, Tan W, Zhang M, Qian J, Lu D, Wu T, Lin D*, Shen H*. Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Cancer Res 2009; 69:5065–5072.



72.Zhao D, Xu D, Zhang X, Wang L, Tan W, Guo Y, Yu D, Li H, Zhao P*, Lin D*. Interaction of cyclooxygenase-2 variantssmoking in pancreatic cancer: A possible role of nucleophosmin. Gastroenterology 2009; 136:1659–1668.



73.Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D*, Liu Z*. Functional role of S100A14 genetic variantstheir association with esophageal squamous cell carcinoma. Cancer Res 2009; 69:3451–3457.



74.Singh P, Yang M, Dai H, Yu D, Huang Q, Tan W, Kernstine KH, Lin D*, Shen B*. Overexpressionhypomethylation of Flap endonuclease 1 gene in breastother cancers. Mol Cancer Res 2008; 6:1710–1717.



75.Sun T, Zhou Y, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D, Tian T, Zhou X, Shen H*, Lin D*. Functional genetic variations in cytotoxic T-lymphocyte antigen 4susceptibility to multiple types of cancer. Cancer Res 2008; 68:7025–7034.



76.Wang Z*, Xu B, Lin D, Tan W, Jeaw S, Hong X, Hu X. XRCC1 polymorphismssevere toxicity in lung cancer patients treated with cisplatin-based chemotherapy in Chinese population. Lung Cancer 2008; 62:99–104.



77.Wang H, Liu Y, Tan W, Zhang Y, Zhao N, Jiang Y, Lin C, Hao B, Zhao D, Qian J, Lu D, Jin L, Wei Q, Lin D*, He F*. Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking. Cancer Sci 2008; 99:787–791.



78.Yang M, Sun T, Wang L, Yu D, Zhang X, Miao X, Liu J, Zhao D, Li H, Tan W, Lin D*. Functional variants in cell death pathway genesrisk of pancreatic cancer. Clin Cancer Res 2008; 14:3230–3236.



79.Yu D, Zhang X, Liu J, Yuan P, Tan W, Guo Y, Sun T, Zhao D, Ming Y, Liu J, Xu B*, Lin D*. Characterization of functional excision repair cross-complementation group 1 variantstheir association with lung cancer riskprognosis. Clin Cancer Res 2008; 14:2878–2886.



80.Hu D, Sun T, Ren W, Zheng H, Liu H, Duan Z, Li L, Tan W, Zhao D, Liu Y, Lin D*, Cao Y*. The polymorphisms on Igκ gene are related to susceptibility of breast cancergastric cancer. Genet Test 2008; 12:575–580.



81.Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, Fang J, Gao C, Gotze T, Graziano F, Lacasana-Navarro M, Lin D, Lopez-Carrillo L, Qiao Y, Shen H, Stolzenberg-Solomon R, Takezaki T, Weng Y, Zhang F, van Duijn CM, Boffetta P, Taioli E*. Meta-pooled analyses of the methylenetetrahydrofolate reductase C677TA1298C polymorphismsgastric cancer risk: a Huge-GSEC review. Am J Epidemiol 2008; 167:505–516.



82.Lin Z, Zhang X, Tu J, Guo Y, Green B, Chan C, Tan W, Huang Y, Ling W, Kadlubar FF, Lin D*, Ning B*. A variant of the Cokyne syndrome B gene ERCC6 confers risk of lung cancer. Hum Mutat 2008; 29:113–122.



83.Lin D*, Li H, Tan W, Miao X, Wang L. Genetic polymorphisms in folate-metabolizing enzymesrisk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development. Forum Nutr 2007; 60:140–145.



84.Yang M, Guo Y, Zhang X, Miao X, Tan W, Sun T, Zhao D, Liu J, Lin D*. Interaction of P53 Arg72ProMDM2 T309G polymorphismstheir associations with risk of gastric cardia cancer. Carcinogenesis 2007; 28:1996–2001.



85.Li Z, Dai H, Zhou M, Li M, Singh P, Qiu J, Tsark W, Huang Q, Kernstine K, Zhang X, Lin D, Shen B*. Fen1 mutations result in autoimmunity, chronic inflammationcancers. Nat Med 2007; 13:812–819.



86.Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q, Zeng C*, Lin D*. A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nat Genet 2007; 39:605–613.



87.Tan W, Wu J, Zhang X, Guo Y, Liu J, Sun T, Zhang B, Zhao D, Yang M, Yu D, Lin D*. Associations of functional polymorphisms in cyclooxygenase-2platelet 12-lipoxygenase with risk of occurrenceadvanced disease status of colorectal cancer. Carcinogenesis 2007; 28:1197–1201.



88.Zhao D, Sun T, Zhang X, Guo Y, Yu D, Yang M, Tan W, Wang G, Lin D*. Role of CD14 promoter polymorphisms in Helicobacter pylori infection related gastric carcinoma. Clin Cancer Res 2007; 13:2362–2368.



89.Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D*. Functional polymorphisms in FASFASL contribute to increased apoptosis of tumor infiltration lymphocytesrisk of breast cancer.Carcinogenesis 2007; 28:1067–1073.



90.Guo Y, Zhang X, Tan W, Miao X, Sun T, Zhao D, Lin D*. Platelet 12-lipoxygenase Arg261Gln polymorphism: Functional characterizationassociation with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.Pharmacogenet Genomics 2007; 17:197–205.



91.Sun T, Gao Y, Tan W, Ma S, Zhang X, Wang Y, Zhang Q, Guo Y, Zhao D, Zeng C*, Lin D*. Haplotypes in matrix metalloproteinase gene cluster on chromosome 11q22 contribute to the risk of lung cancer developmentprogression. Clin Cancer Res 2006; 12:7009–7017.



92.Wang H, Hao B, Chen X, Zhao N, Cheng G, Jiang Y, Liu Y, Lin C, Tan W, Lu D, Wei Q, Jin L, Lin D*, He F*. Beta-2 adrenergic receptor gene (ADRB2) polymorphismrisk for lung adenocarcinoma: A case-control study in a Chinese population. Cancer Lett 2006; 240:297–305.



93.Miao X, Zhang X, Zhang L, Guo Y, Hao B, Tan W, He F*, Lin D*. Adenosine diphosphate ribosyl transferaseX-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. Gastroenterology 2006; 131:420–427.



94.Cao Y, Miao X, Huang M, Deng L, Hu L, Ernberg I, Zeng Y, Lin D*, Shao J*. Polymorphisms of XRCC1 genesrisk of nasopharyngeal carcinoma in the Cantonese population. BMC Cancer 2006; 6:167.



95.Hao B, Miao X, Li Y, Zhang X, Sun T, Liang G, Zhao Y, Zhou Y, Wang H, Chen X, Zhang L, Tan W, Wei Q, Lin D*, He F*. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activityincreased risk of non-small cell lung cancer. Oncogene 2006; 25:3613–3620.



96.Liu F, Pan K, Zhang X, Zhang Y, Zhang L, Ma J, Dong C, Shen L, Li J, Deng D, Lin D, You W*. Genetic variations in cyclooxygenase-2: Expressionrisk of gastric cancerits precursors in a Chinese population. Gastroenterology 2006; 130:1975–1984.



97.Zhang X, Miao X, Guo Y, Xu N, Hong Y, Liu Z, Tan W, Lin D*. Genetic polymorphisms in cell cycle regulatory genes MDM2P53 are associated with susceptibility to lung cancer risk. Hum Mutat 2006; 27:110–117.



98.Li Y, Zhang X, Huang G, Miao X, Guo L, Lin D, Lu S*. Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 (ECRG1)it related risk to esophageal squamous cell carcinoma. Carcinogenesis 2006; 27:798–802.



99.Wang H, Jiang Y, Liu Y, Lin C, Cheng G, Chen X, Hao B, Tan W, Lin D*, He F*. CYP2J2*7 single nucleotide polymorphism in a Chinese population. Clin Chim Acta 2006; 365:125–128.



100.Verkerk AO, Wilders R, Schulze-Bahr E, Beekman L, Bhuiyan ZA, Bertrand J, Eckardt L, Lin D, Borggrefe M, Breithardt G, Mannens MM, Tan H, Wilde AA, Bezzina CR*. Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome. Cardiovasc Res 2005; 68:441–453.



101.Sun T, Zhou Y, Li H, Han X, Shi Y, Wang L, Miao X, Tan W, Zhao D, Zhang X, Guo Y, Lin D*. FASL-844C polymorphism is associated with increased activation induced T-cell deathrisk of cervical cancer. J Exp Med 2005; 202:967–974.



102.Hong Y, Miao X, Zhang X, Guo Y, Tan W, Liu Z*, Lin D*. The role of P53MDM2 polymorphisms in risk of esophageal squamous cell carcinoma. Cancer Res 2005;65:9582–9587.



103.Zhang X, Miao X, Tan W, Ning B, Liu Z, Hong Y, Song W, Guo Y, Zhang X, Shen Y, Qiang B, Kadlubar FF, Lin D*. Identification of functional genetic variants in cyclooxygenase-2their association with risk of esophageal cancer. Gastroenterology 2005; 129:565–576.



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